Analytical Data
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Gene name
HMGB3
- Application
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Alternative Names
HMG2A; HMG4; High mobility group protein 4
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
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Expression Region
Ser14~Ala176
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
High Mobility Group Box 3 (HMGB3) is a member of the high mobility group (HMG) family of proteins, which are characterized by their ability to bind DNA and influence various biological processes, including transcription, DNA repair, and chromatin structure regulation. HMGB3 is primarily expressed during embryonic development and has been implicated in cellular proliferation and differentiation. Recent research has highlighted its role in cancer biology, as aberrant expression of HMGB3 has been associated with tumor progression and metastasis in various cancers. The recombinant expression of HMGB3 protein allows for detailed studies of its molecular functions and interactions with DNA, RNA, and other proteins. Understanding HMGB3’s structure and function can provide insights into its role in maintaining genomic stability and its potential as a therapeutic target in cancer treatment. Moreover, recombinant HMGB3 can be used in cellular assays to investigate its effects on gene expression and to explore its involvement in developmental processes, thereby contributing to a deeper understanding of its physiological and pathological roles. As a result, HMGB3 has garnered attention not only as a fundamental research protein but also as a candidate for drug discovery and development, particularly in the context of cancer therapeutics.
