Analytical Data
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Gene name
KRT6C
- Application
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Alternative Names
KRT6E; Keratin 6E; Keratin, type II cytoskeletal 6C; Cytokeratin-6C; Type-II keratin Kb12
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48668
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Expression Region
Glu163~Gly482
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Molecular Weight
41kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT6C, a member of the keratin family, plays a crucial role in the structural integrity and function of epithelial tissues. It is primarily expressed in stratified epithelial cells, including those in the skin, oral cavity, and respiratory tract. Abnormal expression of KRT6C has been implicated in various dermatological conditions, such as psoriasis and keratoderma. Recent studies have focused on the potential of KRT6C as a biomarker for these skin disorders, as well as its involvement in cellular response to stress and injury. Additionally, KRT6C's role in the cell cycle and its interaction with other cytoskeletal proteins suggest that it may have broader implications in epithelial cell differentiation and proliferation. The use of recombinant KRT6C proteins has provided valuable insights into the mechanistic pathways underlying its function, enabling researchers to explore therapeutic targets for skin diseases. Understanding KRT6C's biological significance could open new avenues in regenerative medicine and tissue engineering, offering hope for improved treatment strategies.
