Analytical Data
-
基因名
LRP3
- Application
-
别名
hLRp105; 105 kDa low-density lipoprotein receptor-related protein
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O75074
-
表达区间
Gln184~Asp435
-
分子量
26kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome has gained significant attention in recent years due to its crucial role in the innate immune response and its implications in various inflammatory diseases. NLRP3 functions as a sensor for a wide array of danger signals, including pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), leading to the activation of caspase-1 and the subsequent release of pro-inflammatory cytokines such as IL-1β and IL-18. Dysregulation of NLRP3 has been associated with numerous conditions, including autoimmune diseases, metabolic syndrome, and neurodegenerative disorders. Consequently, the development of recombinant NLRP3 protein plays a pivotal role in elucidating the molecular mechanisms of inflammasome activation and regulation. By producing recombinant NLRP3 proteins, researchers aim to investigate protein structure, activation pathways, and interactions with other inflammasome components. These studies provide valuable insights into the therapeutic potential of targeting NLRP3 for treating diseases characterized by chronic inflammation. Moreover, recombinant NLRP3 proteins facilitate high-throughput screening of potential drugs or compounds that modulate inflammasome activity, thereby advancing the quest for innovative anti-inflammatory therapies. Overall, the exploration of recombinant NLRP3 protein not only enhances our understanding of innate immune signaling but also serves as a foundation for developing novel strategies to combat NLRP3-related diseases.
