Analytical Data
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Gene name
ACOX3
- Application
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Alternative Names
BRCOX; PRCOX; BRCACox; Branched-chain acyl-CoA oxidase; Pristanoyl-CoA oxidase; Peroxisomal acyl-coenzyme A oxidase 3
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9EPL9
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Expression Region
Ser529~Leu700
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Molecular Weight
23kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACOX3, or acyl-CoA oxidase 3, is a crucial enzyme involved in the peroxisomal beta-oxidation of very long-chain fatty acids. Dysfunctions or mutations in the ACOX3 gene can lead to various metabolic disorders, including peroxisomal biogenesis disorders and fatty acid oxidation defects, which manifest through a range of clinical symptoms such as neurological issues and accumulation of toxic lipid intermediates. Understanding the structure and function of ACOX3 is essential for elucidating its role in metabolic pathways and developing potential therapeutic strategies for associated diseases. Recent advancements in recombinant protein technology have made it feasible to produce ACOX3 in large quantities, allowing researchers to conduct detailed biochemical analyses. By exploring its enzymatic properties, substrate specificity, and regulatory mechanisms, scientists aim to gain insights into how ACOX3 contributes to fatty acid metabolism and its implications in human health. This research not only enhances our understanding of metabolic diseases but also opens avenues for novel interventions targeting ACOX3-related pathways.
