Analytical Data
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Gene name
ABCG5
- Application
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Alternative Names
ABC-G5; STSL; Sterolin 1; ATP-binding cassette sub-family G member 5
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99PE8
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Expression Region
Asp66~Gly276
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Molecular Weight
30&27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCG5 is a member of the ATP-binding cassette (ABC) transporter family, specifically involved in sterol transport, which plays a crucial role in cholesterol and phytosterol metabolism. Mutations or dysfunction in ABCG5 have been linked to diseases such as sitosterolemia, a rare genetic disorder characterized by the abnormal accumulation of plant sterols in the body, leading to premature atherosclerosis. The study of ABCG5 and its recombinant protein is significant for understanding the mechanisms of sterol absorption and the regulation of lipid homeostasis. Research on ABCG5 has focused on elucidating its structure, function, and interaction with other proteins in the cell membrane. The recombinant form of this protein allows for a detailed examination of its transport activity and the effects of specific mutations. Additionally, investigating ABCG5's role in cellular processes aids in identifying potential therapeutic targets for managing hypercholesterolemia and related metabolic disorders. As our understanding of ABCG5 deepens, it could pave the way for innovative treatments that modulate lipid metabolism and address cardiovascular diseases stemming from dyslipidemia. Thus, the research on ABCG5 recombinant protein is vital for both basic and translational science, offering insights into cholesterol regulation and possible pathways to novel therapeutic interventions.
