Analytical Data
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基因名
ABCC3
- Application
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别名
ABC31; MLP2; MOATD; MRP3; cMOAT2; Canalicular Multispecific Organic Anion Transporter 2; Multi-specific organic anion transporter D; Multidrug resistance-associated protein 3
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15438
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表达区间
Phe1291~Asp1523
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC3, also known as the Multidrug Resistance Protein 3 (MRP3), is a member of the ATP-binding cassette (ABC) transporter family, which plays a vital role in cellular transport processes. Research on ABCC3 has gained prominence due to its involvement in drug resistance, particularly in cancer therapy. Overexpression of ABCC3 has been linked to the efflux of a wide variety of substrates, including chemotherapeutic agents, thereby diminishing their efficacy and contributing to the challenge of successful cancer treatment. Additionally, ABCC3 is implicated in the transport of bile acids and xenobiotics, which underscores its significance in hepatic function and homeostasis. The functional characterization of ABCC3 through recombinant protein studies allows researchers to elucidate the mechanistic pathways governing drug transport and resistance. Understanding how ABCC3 operates at the molecular level may reveal potential therapeutic strategies to combat drug resistance in various malignancies. Furthermore, research on ABCC3 can illuminate its role in pharmacokinetics and drug interactions, enabling the design of more effective therapeutic regimens tailored to individual patient needs. Overall, the study of ABCC3 and its recombinant protein forms is critical for advancing our knowledge of drug transport mechanisms and improving outcomes in cancer treatment.
