Analytical Data
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Gene name
ABCC2
- Application
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Alternative Names
CMOAT1; ABC30; CMOAT; DJS; MRP2; cMRP; Canalicular Multispecific Organic Anion transporter 1; Canalicular multidrug resistance protein; Multidrug resistance-associated 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92887
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Expression Region
Ile1300~Glu1534
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC2, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the elimination of various endogenous and exogenous compounds in the liver and intestines. Its primary function revolves around the transport of conjugated bile acids, drugs, and toxins across cellular membranes, thereby influencing pharmacokinetics and drug disposition. Dysregulation or mutations in ABCC2 have been implicated in several health issues, including drug resistance in cancer therapy, liver diseases, and metabolic disorders. The understanding of ABCC2's structure and function is vital for developing targeted therapies and improving drug delivery systems. Recombinant protein studies of ABCC2 have emerged as an important area of research, enabling scientists to investigate the mechanistic details of its transport activities, interactions with various substrates, and the impact of genetic variations. These studies utilize expression systems to generate large quantities of the protein for detailed biochemical assays and structural analyses, providing insights into its role in cellular processes and potential therapeutic applications. This research not only enhances our understanding of ABCC2’s biological functions but also paves the way for innovative strategies to overcome challenges related to drug absorption and resistance, ultimately contributing to more effective treatments for various diseases.
