Analytical Data
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Gene name
SCNN1b
- Application
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Alternative Names
ENaCb; ENaCbeta; SCNEB; Liddle Syndrome; Sodium Channel,Nonvoltage-Gated 1,Beta; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51168
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Expression Region
Tyr504~Ile640
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Molecular Weight
45kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SCNN1B, or Sodium Channel Epithelial 1 Beta Subunit, plays a crucial role in regulating epithelial sodium channels (ENaCs), which are essential for sodium balance, blood pressure regulation, and fluid homeostasis. Its dysfunction is linked to various pathophysiological conditions, including hypertension, pulmonary edema, and cystic fibrosis. Researchers focus on recombinant SCNN1B proteins to better understand the molecular mechanisms underlying ENaC function and regulation. The production of recombinant SCNN1B allows for detailed structural and functional studies, enabling scientists to investigate how specific mutations affect channel activity and interactions with other regulatory proteins. Additionally, recombinant SCNN1B offers a valuable tool for drug discovery, aiming to identify potential therapeutic compounds that can modulate ENaC activity in various diseases. Overall, the investigation of SCNN1B recombinant proteins represents a significant advancement in the field of cellular physiology and has potential implications for developing treatments for sodium-related disorders.
