Analytical Data
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基因名
SCNN1b
- Application
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别名
ENaCb; ENaCbeta; SCNEB; Liddle Syndrome; Sodium Channel,Nonvoltage-Gated 1,Beta; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51168
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表达区间
Tyr504~Ile640
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分子量
45kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCNN1B, or Sodium Channel Epithelial 1 Beta Subunit, plays a crucial role in regulating epithelial sodium channels (ENaCs), which are essential for sodium balance, blood pressure regulation, and fluid homeostasis. Its dysfunction is linked to various pathophysiological conditions, including hypertension, pulmonary edema, and cystic fibrosis. Researchers focus on recombinant SCNN1B proteins to better understand the molecular mechanisms underlying ENaC function and regulation. The production of recombinant SCNN1B allows for detailed structural and functional studies, enabling scientists to investigate how specific mutations affect channel activity and interactions with other regulatory proteins. Additionally, recombinant SCNN1B offers a valuable tool for drug discovery, aiming to identify potential therapeutic compounds that can modulate ENaC activity in various diseases. Overall, the investigation of SCNN1B recombinant proteins represents a significant advancement in the field of cellular physiology and has potential implications for developing treatments for sodium-related disorders.
