Analytical Data
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Gene name
PSMC1
- Application
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Alternative Names
P26S4; S4; p56; 26S proteasome AAA-ATPase subunit RPT2; 26S protease regulatory subunit 4
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62191
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Expression Region
Met1~Leu440
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Molecular Weight
53kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMC1, or proteasome 26S subunit ATPase 1, is a vital component of the 26S proteasome, a complex responsible for degrading ubiquitinated proteins in eukaryotic cells. This process is crucial for various cellular functions, including the regulation of the cell cycle, modulation of signaling pathways, and the maintenance of protein homeostasis. Recent studies have highlighted the significance of PSMC1 in cancer biology, where its dysregulation is often linked to tumor progression and resistance to therapy. The overexpression of PSMC1 has been observed in several cancer types, suggesting it may function as an oncogene. Furthermore, PSMC1's role in the unfolding and translocation of substrate proteins into the proteasome has garnered attention for potential therapeutic interventions. The recombinant expression and study of PSMC1 provide insights into its structure-function relationship, enzymatic activity, and interaction with other proteasome subunits. As researchers explore PSMC1 as a biomarker for malignancies and a potential target for drug development, understanding its mechanisms of action and regulatory pathways has become increasingly important in the context of targeted therapies and personalized medicine. The ongoing investigation into PSMC1 and its reconstituted proteins aims to unveil new avenues for cancer treatment and provide a foundational understanding of proteasomal regulation in normal and pathological states.
