Analytical Data
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基因名
Nr2c2
- Application
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别名
Orphan nuclear receptor TAK1Orphan nuclear receptor TR4Testicular receptor 4
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49116
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表达区间
3-592aa
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分子量
68.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nr2c2, also known as steroid receptor coactivator 1 (SRC-1) or neuronal PAS domain protein 2 (NPAS2), is a member of the nuclear receptor superfamily, playing a crucial role in various physiological processes, including metabolism, reproduction, and neurodevelopment. Its ability to regulate gene expression in response to hormonal and nutrient signals makes it a critical regulator of cellular homeostasis. Alterations in Nr2c2 function have been implicated in several disorders, including metabolic syndromes and neurodegenerative diseases. Research into recombinant Nr2c2 protein has gained momentum due to its potential as a therapeutic target. By producing and characterizing this protein, scientists aim to unravel its complex mechanisms of action at molecular and cellular levels, as well as its interactions with other coactivators and transcription factors. Understanding these interactions can provide insights into its role in gene regulation, offering avenues for developing novel strategies to manipulate its activity for therapeutic interventions in diseases linked to its dysregulation. The generation of Nr2c2 recombinant protein also facilitates the exploration of its structural properties and ligand-binding characteristics, which are essential for drug design and discovery. Overall, the study of Nr2c2 recombinant protein is poised to contribute significantly to our understanding of nuclear receptor biology and its applications in medicine.
