Analytical Data
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基因名
PYCARD
- Application
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别名
Caspase recruitment domain-containing protein 5 (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (ASC) (CARD5) (TMS1)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9ULZ3
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表达区间
1-195aa
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分子量
29.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PYCARD, also known as ASC (apoptosis-associated speck-like protein containing a CARD), is a crucial adaptor protein involved in the immune response and inflammation. It plays a significant role in the formation of multiprotein complexes known as inflammasomes, which are critical for the activation of inflammatory caspases and the subsequent processing of pro-inflammatory cytokines like IL-1β and IL-18. The dysregulation of PYCARD and its associated pathways has been linked to various inflammatory diseases, autoimmune disorders, and even cancer, making it a target of interest in biomedical research. Studies have shown that PYCARD can interact with several other proteins, including pathogen-associated molecular pattern receptors, which further highlights its integral role in the innate immune system. The recombinant production of PYCARD protein allows researchers to study its structure, function, and interactions in a controlled environment, providing insights into how alterations in its signaling pathways contribute to disease. Understanding PYCARD's mechanisms could pave the way for novel therapeutic strategies aimed at modulating inflammatory responses in various clinical conditions. This area of research continues to be pivotal, particularly with increasing interest in targeting inflammasome-related pathways for the treatment of inflammatory diseases.
