Cat: IPD-X38676

Recombinant Human CCNB2 Protein,His

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Analytical Data

  • 基因名

    CCNB2

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CCN-B2; G2/mitotic-specific cyclin-B2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    O95067

  • 表达区间

    Val58~Ser398

  • 分子量

    43kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

CCNB2, or Cyclin B2, is a crucial regulatory protein involved in the control of the cell cycle, particularly during the transition from the G2 phase to mitosis. As a member of the cyclin family, CCNB2 partners with cyclin-dependent kinases (CDKs), specifically CDK1, to form a complex that drives the phosphorylation of target proteins, thereby promoting the progression of cell division. Research has shown that aberrations in CCNB2 expression and activity are associated with various cancers, suggesting its potential role as a biomarker for tumorigenesis and disease progression. The need for CCNB2-derived recombinant proteins arises from their potential applications in understanding cell cycle dynamics and developing targeted therapies. The production of these proteins enables detailed studies into their structure-function relationships, interactions with other cell-cycle regulators, and contributions to oncogenic processes. Furthermore, recombinant CCNB2 can facilitate high-throughput screening of novel compounds that may modulate its activity, paving the way for therapeutic innovations in cancer treatment. In recent years, advancements in protein engineering and expression systems have enhanced the yield and functionality of recombinant CCNB2, making it a valuable tool for both basic and applied research in oncology. The ongoing investigations into CCNB2's roles necessitate a comprehensive understanding of its biochemical properties and interactions, underscoring the importance of topical research involving its recombinant forms. Thus, the exploration of recombinant CCNB2 not only enriches our comprehension of cell cycle regulation but also offers promising avenues for clinical applications in cancer therapy.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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