Analytical Data
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基因名
DDR2
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简介
The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. Immobilized Collagen I at 10 µg/mL can bind Rhesus Macaque DDR2 with an apparent KD is 7.846 nM. Measured by its binding ability in a functional ELISA. Immobilized Collagen I at 10 µg/mL can bind Rhesus Macaque DDR2 with an apparent KD is 7.846 nM.
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别名
Discoidin domain-containing receptor 2; CD167b; Ddr2; Ntrkr3; Tkt; Tyro10
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种属
Rhesus Macaque
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
XP_001118219.1
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表达区间
K22-R399
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氨基酸序列
QVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMTPTTYDPMLKIDDSNTR
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蛋白长度
Partial
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分子量
50-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDR2 (Discoidin Domain Receptor 2) is a receptor tyrosine kinase that plays a significant role in the regulation of cellular processes such as proliferation, differentiation, and extracellular matrix remodeling. It is primarily expressed in mesenchymal tissues and has garnered attention due to its involvement in various pathological conditions, including fibrosis, cancer metastasis, and cardiovascular diseases. DDR2 interacts with collagen and other components of the extracellular matrix, leading to activation of downstream signaling pathways that influence cellular behavior. Research on recombinant DDR2 proteins has expanded our understanding of its structural and biochemical properties, enabling the exploration of its functions in physiological and pathological contexts. Moreover, recombinant DDR2 has potential applications in drug development, where it can serve as a target for therapeutic intervention in diseases linked to dysregulated ECM interactions. The elucidation of DDR2's mechanisms and interactions through recombinant protein studies could pave the way for novel strategies to combat fibrotic diseases and improve cancer treatment outcomes. The ongoing investigation into the role of DDR2 in cell-matrix interactions underscores its importance in maintaining tissue homeostasis and its potential as a biomarker or therapeutic target in various diseases, making it a focal point of current biomedical research.
