Analytical Data
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基因名
Dynamitin (DCTN2)
- Application
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别名
DCTN50; DYNAMITIN; HEL-S-77; RBP50
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
NP_006391
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表达区间
M1-K406
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氨基酸序列
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
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蛋白长度
Full Length
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分子量
56-70 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dynamitin, encoded by the DCTN2 gene, is a critical component of the dynactin complex, which plays a crucial role in intracellular transport and mitosis. The dynactin complex is essential for the function of motor proteins, particularly dynein, facilitating the retrograde transport of vesicles along microtubules. Dysregulation or mutations in DCTN2 are associated with various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, making its study pertinent for understanding the underlying mechanisms of these conditions. The generation of recombinant Dynamitin protein allows researchers to explore its structural characteristics, functional interactions, and the impact of specific mutations. By employing techniques such as biochemical assays, microscopy, and protein interaction studies, scientists aim to uncover how alterations in Dynamitin influence cellular transport processes and contribute to disease pathology. This research not only enhances our understanding of cellular dynamics but also holds potential for developing targeted therapeutic strategies for related neurodegenerative disorders.
