Analytical Data
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基因名
PICALM
- Application
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别名
LAP; CALM; CLTH; Clathrin assembly lymphoid myeloid leukemia protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13492
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表达区间
Gly19~Leu285
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分子量
40&34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PICALM (Phosphatidylinositol-binding clathrin-AP180-kinase interacting protein) is a key protein implicated in synaptic function and endocytosis, contributing to the regulation of clathrin-mediated trafficking in neurons. Its association with Alzheimer's disease has garnered significant attention, as genetic studies have shown that variants in the PICALM gene can influence the risk of developing the disease. This connection underlines the importance of PICALM in amyloid precursor protein processing and the subsequent accumulation of amyloid-beta, a hallmark of Alzheimer's pathology. Research has focused on the structural and functional aspects of PICALM, revealing its role in synaptic vesicle recycling and neuronal signaling. To further understand its mechanisms, scientists have undertaken studies to express and purify recombinant PICALM protein in various systems, aiming to analyze its interactions with other synaptic proteins and lipid environments. By investigating the properties and interactions of PICALM, researchers hope to elucidate its contributions to synaptic health and its potential implications in neurodegenerative diseases, laying the groundwork for future therapeutic strategies targeting PICALM-related pathways.
