Analytical Data
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Gene name
TNKS2
- Application
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Alternative Names
PARP5B; PARP5C; TANK2; TNKL; Tankyrase-like protein; ADP-ribosyltransferase diphtheria toxin-like 6; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2K2
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Expression Region
Ser959~Gly1166
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TNKS2 (Tankyrase 2) is a member of the tankyrase family of enzymes, which are important for various cellular processes, including telomere maintenance, Wnt signaling, and the regulation of several protein interactions through ADP-ribosylation. Research on TNKS2 has gained attention due to its potential role in cancer progression and other diseases. Unlike its closely related counterpart TNKS1, TNKS2 is less well-characterized, but studies suggest that it may be involved in the modulation of cellular pathways that contribute to tumorigenesis. The investigation of TNKS2 and its enzymatic functions has implications for the development of targeted therapies, as inhibiting its activity could disrupt aberrant signaling pathways that are commonly activated in cancers. Additionally, understanding the structural and biochemical properties of TNKS2 can provide insights into its mechanism of action and interaction with other proteins. Recent advances in recombinant protein technology have enabled the production of TNKS2 in sufficient quantities for detailed study, paving the way for high-throughput screening of small molecules that may serve as potential therapeutics. This growing body of research aims to elucidate the roles of TNKS2 in cellular homeostasis and disease, ultimately contributing to the discovery of novel treatment strategies for cancers and other related disorders.
