Analytical Data
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基因名
TNKS2
- Application
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别名
PARP5B; PARP5C; TANK2; TNKL; Tankyrase-like protein; ADP-ribosyltransferase diphtheria toxin-like 6; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2K2
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表达区间
Ser959~Gly1166
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNKS2 (Tankyrase 2) is a member of the tankyrase family of enzymes, which are important for various cellular processes, including telomere maintenance, Wnt signaling, and the regulation of several protein interactions through ADP-ribosylation. Research on TNKS2 has gained attention due to its potential role in cancer progression and other diseases. Unlike its closely related counterpart TNKS1, TNKS2 is less well-characterized, but studies suggest that it may be involved in the modulation of cellular pathways that contribute to tumorigenesis. The investigation of TNKS2 and its enzymatic functions has implications for the development of targeted therapies, as inhibiting its activity could disrupt aberrant signaling pathways that are commonly activated in cancers. Additionally, understanding the structural and biochemical properties of TNKS2 can provide insights into its mechanism of action and interaction with other proteins. Recent advances in recombinant protein technology have enabled the production of TNKS2 in sufficient quantities for detailed study, paving the way for high-throughput screening of small molecules that may serve as potential therapeutics. This growing body of research aims to elucidate the roles of TNKS2 in cellular homeostasis and disease, ultimately contributing to the discovery of novel treatment strategies for cancers and other related disorders.
