Analytical Data
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Gene name
REG4
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简介
The REG4 protein is a calcium-dependent lectin that functions as a pattern recognition receptor (PRR) in the innate immune system. REG4 has specific affinity for α-mannan on Candida albicans hyphae and triggers phosphorylation of the FCER1G immunoreceptor tyrosine activation motif (ITAM), thereby activating SYK, CARD9 and NF-kappa-B. REG4 Protein, Rat (HEK293, His) is the recombinant rat-derived REG4 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Regenerating islet-derived protein 4; GISP; RELP; REG4
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Species
Rat
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q68AX7
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Expression Region
D23-P157
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Protein Length
Full Length of Mature Protein
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Molecular Weight
20-31 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
REG4, a member of the regenerating gene family, has garnered attention in recent years due to its association with various physiological and pathological processes, particularly in gastrointestinal tissues. Originally identified for its role in promoting epithelial regeneration following injury, REG4 has since been implicated in several conditions, including inflammatory bowel disease (IBD), colorectal cancer, and pancreatitis. Studies suggest that REG4 may play a critical role in the modulation of inflammation and tissue repair, making it a potential biomarker for disease diagnosis and prognosis. Its expression levels have been correlated with disease severity, indicating its utility in understanding disease progression. Furthermore, the molecular mechanisms underlying REG4 function are being investigated, focusing on its signaling pathways and interactions with other cellular components. As researchers continue to explore REG4's roles across different biological contexts, insights into its therapeutic potential are rapidly emerging, positioning REG4 as a valuable target for developing novel strategies in treating gastrointestinal diseases and beyond.
