Analytical Data
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基因名
HLA-DQA2
- Application
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别名
DX alpha chainHLA class II histocompatibility antigen, DQ(6) alpha chainHLA-DQA1MHC class II DQA2
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01906
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表达区间
24-214aa
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分子量
25.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-DQA2 is a crucial component of the human major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune system by presenting peptide antigens to CD4+ T cells. Understanding the structure and function of HLA-DQA2 is essential for insights into immune recognition and responses, particularly in the context of autoimmune diseases, allergies, and transplant rejection. Research on recombinant HLA-DQA2 proteins has garnered interest due to their potential applications in immunotherapy, vaccine development, and understanding disease susceptibility linked to genetic variations in MHC genes. The production of recombinant HLA-DQA2 allows for detailed studies of its interactions with peptides and T cell receptors, enhancing our understanding of antigen presentation mechanisms. Furthermore, elucidating the x-ray crystallographic structure of HLA-DQA2 in complex with specific peptides can provide crucial information regarding binding preferences and the subsequent immune response. This research is particularly relevant in studying population genetics, as variations in HLA-DQA2 can influence the prevalence of certain diseases across different ethnic groups. Overall, the investigation of HLA-DQA2 and its recombinant proteins is pivotal in advancing our knowledge of the immune system and developing novel therapeutic strategies against various diseases.
