Analytical Data
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基因名
NOVA1
- Application
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别名
Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1; RNA-binding protein Nova-1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51513
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表达区间
Ala292~Gly507
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOVA1 is a member of the Nova family of RNA-binding proteins that play crucial roles in the regulation of alternative splicing, a fundamental process in gene expression. Studying NOVA1 is significant as it is implicated in various neurodevelopmental disorders and the progression of certain cancers. Originally identified for its involvement in the central nervous system, NOVA1 contributes to the splicing of pre-mRNAs, influencing neuronal differentiation and synaptic function. Research has revealed that dysregulation of NOVA1 can lead to aberrant splicing events, which are linked to diseases such as autism spectrum disorders and specific types of brain tumors. Moreover, NOVA1's interaction with RNA influences cellular responses to stress, making it a potential target for therapeutic interventions. By exploring NOVA1 recombinant protein, researchers aim to better understand its structure, function, and the molecular mechanisms underlying its role in health and disease. Investigating NOVA1 may provide insights into novel treatment strategies for disorders where splicing misregulation is a key factor. Overall, NOVA1 is a pivotal focus in the realm of molecular biology, with ongoing research efforts aimed at elucidating its contribution to fundamental biological processes and disease pathology.
