Analytical Data
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Gene name
XBP1
- Application
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Alternative Names
TREB5; XBP2; Tax-responsive element-binding protein 5
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Species
Mouse
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O35426
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Expression Region
Met1~Leu267
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Molecular Weight
60kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XBP1 (X-box binding protein 1) is a crucial transcription factor that plays a significant role in the cellular response to endoplasmic reticulum (ER) stress and the regulation of unfolded protein response (UPR). It is primarily generated through unconventional splicing of XBP1 mRNA, resulting in the production of a potent active form that drives the expression of genes involved in protein folding, ER expansion, and apoptosis. Dysregulation of XBP1 has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders, making it a critical target for therapeutic intervention. The study of XBP1 recombinant protein is essential for understanding its functional mechanisms, particularly in the context of ER stress responses and its role in maintaining cellular homeostasis. By producing recombinant XBP1, researchers can explore its binding interactions, regulatory functions, and potential as a biomarker for disease states. Furthermore, such studies help elucidate the pathways that XBP1 governs, offering insights into how modulation of this factor could influence disease progression and treatment outcomes. As research progresses, XBP1 may emerge as a pivotal component in drug development, particularly in therapeutics aimed at restoring normal cellular functions in diseased states characterized by ER stress and UPR dysregulation. This growing interest in XBP1 highlights its significance in both fundamental biology and clinical applications, paving the way for innovative strategies to manage diseases associated with ER dysfunction.
