Analytical Data
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基因名
CIB2
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简介
CIB2 protein: Calcium and integrin-binding protein involved in intracellular calcium regulation, auditory hair cell mechanotransduction, and maintenance of stereocilia bundle morphology. CIB2 Protein, Human (His) is the recombinant human-derived CIB2 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP2
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O75838-1
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表达区间
M1-I187
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氨基酸序列
MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI
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蛋白长度
Full Length of Isoform-1
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CIB2 (Calcium and Integrin Binding Protein 2) is an important calcium-binding protein that plays a critical role in various cellular processes, including cell adhesion, migration, and signaling pathways. The study of CIB2 has gained attention due to its involvement in several physiological and pathological conditions, including cardiac function and neurological disorders. Low CIB2 expression has been associated with heart diseases, while its dysregulation may influence neuronal survival and development. Furthermore, CIB2 interacts with integrins, which are essential for cell adhesion and communication with the extracellular matrix, highlighting its significance in mechanical signaling and cellular responses to external stimuli. Research into recombinant CIB2 aims to elucidate its structural properties and functional mechanisms, which can lead to potential therapeutic applications. By producing recombinant CIB2 in heterologous systems, scientists can study its interactions at a molecular level and investigate its role in cellular functions. This work is essential for understanding how CIB2 contributes to cellular health and disease, paving the way for novel interventions in related medical conditions. Overall, the study of CIB2 not only enhances our understanding of fundamental biological processes but also contributes to the development of targeted therapies that could ameliorate diseases associated with its dysfunction.
