Analytical Data
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Gene name
UCK2
- Application
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Alternative Names
UK; UMPK; Uridine Monophosphate Kinase; Cytidine monophosphokinase 2; Testis-specific protein TSA903; Uridine monophosphokinase 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZX2
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Expression Region
Gly18~His261
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The UCK2 (uridine-cytidine kinase 2) protein has garnered significant attention in recent years due to its essential role in nucleoside metabolism and potential implications in cancer therapy. UCK2 is primarily involved in the phosphorylation of uridine and cytidine, converting them into their respective monophosphate forms, which are crucial for nucleotide synthesis and, consequently, RNA and DNA biosynthesis. Dysregulation of UCK2 activity has been implicated in various malignancies, making it a target of interest in cancer research. Studies have shown that elevated levels of UCK2 can promote tumor cell proliferation and survival, suggesting that inhibition of its activity may offer therapeutic benefits. Furthermore, UCK2 is considered a promising biomarker for certain types of cancers, which has spurred interest in the development of specific inhibitors. The ability to produce recombinant UCK2 proteins allows for in-depth structural and functional studies, enabling researchers to explore its enzymatic mechanisms and interactions with potential inhibitors. Overall, UCK2's critical involvement in nucleoside metabolism and its association with tumorigenesis underscore its relevance in biomedical research, paving the way for novel strategies in cancer treatment and diagnosis.
