Analytical Data
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Gene name
Troponin C/TNNC1
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简介
Troponin C, represented by the TNNC1 gene, centrally regulates striated muscle contraction. In the troponin complex consisting of Tn-I, Tn-T, and Tn-C, Tn-I inhibits the actomyosin ATPase, while Tn-T binds to tropomyosin. Troponin C/TNNC1 Protein, Human (N-His) is the recombinant human-derived Troponin C/TNNC1 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
CMH7; TNNC1; TNNI3; Troponin I
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63316
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Expression Region
M1-E161
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Troponin C (TNNC1) is a key component of the troponin complex, which plays a crucial role in muscle contraction and relaxation in skeletal and cardiac muscle tissue. The regulation of muscle contraction is essential for effective heart function and overall locomotion. Dysregulation of troponin C can lead to various cardiac and skeletal muscle diseases, including hypertrophic cardiomyopathy and muscular dystrophies. Due to its significant role in muscle physiology, TNNC1 has garnered attention in both basic research and clinical studies. Researchers have focused on the recombinant expression of troponin C to better understand its structure-function relationship and the effects of mutations associated with myopathies. Recombinant proteins allow for detailed biochemical studies, including binding affinity assays and structural analyses, providing insights into how troponin C interacts with calcium ions and other troponin components. Furthermore, investigating TNNC1 through recombinant techniques has potential therapeutic implications, as engineered variants could be used to develop novel treatments for troponin-related diseases or to modulate muscle function in various conditions. Overall, the study of TNNC1 recombinant proteins is pivotal for advancing our understanding of muscle biology and developing targeted therapies for muscle-related disorders.
