Analytical Data
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基因名
Troponin C/TNNC1
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简介
Troponin C, represented by the TNNC1 gene, centrally regulates striated muscle contraction. In the troponin complex consisting of Tn-I, Tn-T, and Tn-C, Tn-I inhibits the actomyosin ATPase, while Tn-T binds to tropomyosin. Troponin C/TNNC1 Protein, Human (N-His) is the recombinant human-derived Troponin C/TNNC1 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
CMH7; TNNC1; TNNI3; Troponin I
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P63316
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表达区间
M1-E161
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蛋白长度
Full Length
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Troponin C (TNNC1) is a key component of the troponin complex, which plays a crucial role in muscle contraction and relaxation in skeletal and cardiac muscle tissue. The regulation of muscle contraction is essential for effective heart function and overall locomotion. Dysregulation of troponin C can lead to various cardiac and skeletal muscle diseases, including hypertrophic cardiomyopathy and muscular dystrophies. Due to its significant role in muscle physiology, TNNC1 has garnered attention in both basic research and clinical studies. Researchers have focused on the recombinant expression of troponin C to better understand its structure-function relationship and the effects of mutations associated with myopathies. Recombinant proteins allow for detailed biochemical studies, including binding affinity assays and structural analyses, providing insights into how troponin C interacts with calcium ions and other troponin components. Furthermore, investigating TNNC1 through recombinant techniques has potential therapeutic implications, as engineered variants could be used to develop novel treatments for troponin-related diseases or to modulate muscle function in various conditions. Overall, the study of TNNC1 recombinant proteins is pivotal for advancing our understanding of muscle biology and developing targeted therapies for muscle-related disorders.
