Analytical Data
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Gene name
ENDOG
- Application
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Alternative Names
ENDO-G
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14249
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Expression Region
Ala49~Lys297
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Molecular Weight
34/36kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ENDOG (Endonuclease G) is a mitochondrial enzyme that plays a crucial role in apoptosis and mitochondrial homeostasis. Its involvement in the regulation of cell death processes has attracted considerable interest in the fields of cancer research and neurodegenerative diseases. ENDOG is implicated in the cleavage of mitochondrial DNA, which is essential for cellular energy metabolism and the maintenance of mitochondrial integrity. Additionally, aberrations in ENDOG activity have been linked to various pathological conditions, highlighting its potential as a therapeutic target. Research on recombinant ENDOG proteins aims to elucidate their functional mechanisms and interactions within cellular pathways. By expressing ENDOG in heterologous systems, scientists can study its enzymatic properties, substrate specificity, and effects on apoptosis. Understanding the structure-function relationships of ENDOG can inform the design of small molecule inhibitors or activators, paving the way for novel therapeutic strategies. Furthermore, recombinant ENDOG can be utilized in biochemical assays and high-throughput screening approaches to identify compounds that modulate its activity, thus contributing to the development of targeted treatments for diseases associated with mitochondrial dysfunction. Overall, the study of recombinant ENDOG not only enhances our understanding of fundamental mitochondrial processes but also holds promise for advancing the treatment of diverse diseases characterized by dysregulated apoptosis.
