Analytical Data
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Gene name
CIB1
- Application
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Alternative Names
CIB; KIP; SIP2-28; CIBP; PRKDCIP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; SNK-interacting protein 2-28
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99828
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Expression Region
Gly2~Leu191
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CIB1, or Calmodulin-Binding Protein 1, is a calcium-binding protein that plays a crucial role in various cellular processes, including cell signaling, proliferation, and survival. The study of CIB1 has garnered attention due to its involvement in multiple diseases, particularly cancer, where it is thought to modulate cell growth and migration. Recent research has indicated that CIB1 interacts with several key signaling pathways, such as those involving integrins and growth factors, underscoring its potential as a therapeutic target. Additionally, CIB1's ability to bind to calmodulin suggests that it may act as a regulator of calcium-mediated signaling, further implicating it in fundamental physiological processes. The reconstitution of CIB1 as a recombinant protein allows for detailed investigations into its structure-function relationships and interactions with other biomolecules. Understanding CIB1’s specific roles and mechanisms in both normal physiology and pathological conditions could pave the way for developing novel therapeutic strategies aimed at modulating its activity in disease contexts. Overall, the exploration of CIB1 as a recombinant protein is a significant endeavor that may unveil new insights into cellular signaling pathways and their implications in health and disease.
