Analytical Data
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Gene name
FABP1/L-FABP
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简介
FABP1/L-FABP Protein facilitates cholesterol uptake in hepatocytes via lipoproteins, binding cholesterol, free fatty acids, coenzyme A derivatives, bilirubin, and small molecules within the cytoplasm. It may also participate in intracellular lipid transport processes. FABP1/L-FABP Protein, Mouse (His) is the recombinant mouse-derived FABP1/L-FABP protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Fabp1; FabplFatty acid-binding protein; liver; 14 kDa selenium-binding protein; Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP
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Species
Mouse
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P12710
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Expression Region
M1-I127
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Protein Length
Full Length
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FABP1, also known as liver fatty acid-binding protein (L-FABP), is a member of the fatty acid-binding protein family that plays a critical role in the intracellular transport and metabolism of long-chain fatty acids. Its expression is predominantly found in the liver, where it facilitates lipids' uptake, storage, and utilization. Research on FABP1/L-FABP has gained significance due to its involvement in various metabolic disorders, including obesity, insulin resistance, and fatty liver diseases. Abnormal expressions of L-FABP have been linked to the pathogenesis of these conditions, making it a potential biomarker for metabolic syndromes. Moreover, L-FABP is thought to regulate inflammatory processes and has been associated with the development of atherosclerosis. The recombinant production of FABP1/L-FABP enables researchers to study its structure-function relationships, interactions with fatty acids, and potential therapeutic applications. Characterizing the recombinant protein can provide insights into its biological functions and assist in developing targeted interventions for related diseases. Understanding the mechanisms underlying FABP1's role in lipid metabolism may lead to novel strategies for managing metabolic-related health issues. As such, the study of recombinant FABP1/L-FABP is a rapidly expanding field that holds promise for both basic research and clinical applications in the context of metabolic health.
