Analytical Data
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Gene name
IL-17A
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简介
The IL-17A protein has important heterodimerization and homodimerization activities and is involved in a variety of processes, including responses to glucocorticoid stimulation and the regulation of cell death and transcription. IL-17A is present in the cytoplasm and extracellular space and has been implicated in diseases such as pancreatitis, inflammatory bowel disease, renal disease, and periodontal disease, and may serve as a biomarker. IL-17A Protein, Rat (CHO) is the recombinant rat-derived IL-17A protein, expressed by CHO , with tag free.
- Application
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Biological Activity
Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 1-7 ng/mL. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is <7>1.43×105 U/mg.
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Alternative Names
Il17a; interleukin 17A; Il17; IL-17; CTLA-8; IL-17A; interleukin-17A; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17
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Species
Rat
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Source
CHO
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Tag
Tag Free
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
G3V7M4
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Expression Region
A26-S158
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Protein Length
Full Length of Mature Protein
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Molecular Weight
16-22 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine predominantly produced by a subset of T-helper cells known as Th17 cells. Its discovery has significantly advanced our understanding of immune responses, particularly in autoimmune diseases, chronic inflammatory conditions, and certain infections. Elevated levels of IL-17A have been implicated in various pathologies such as rheumatoid arthritis, psoriasis, and multiple sclerosis, highlighting its role as a key mediator of inflammation. Research into recombinant IL-17A protein has gained momentum due to its potential applications in therapeutic interventions and vaccine development. Scientists are exploring ways to manipulate IL-17A signaling pathways to either enhance immune responses against tumors or inhibit its activity to alleviate autoimmune disorders. Additionally, the study of recombinant IL-17A has provided insights into its structure-function relationships, facilitating the design of specific inhibitors and agonists. This research holds promise not only for the development of novel biologic therapies but also for diagnostics and monitoring disease progression. As our understanding of IL-17A continues to evolve, it underscores the importance of targeted interventions aimed at modulating its activity in various clinical settings, ultimately paving the way for more effective treatments for inflammatory diseases.
