Analytical Data
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Gene name
WDR1
- Application
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Alternative Names
Actin-interacting protein 1 ;AIP1NORI-1
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75083
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Expression Region
189-461aa
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Molecular Weight
56.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR1 (WD repeat domain 1) is a critically important protein that plays a significant role in the regulation of the actin cytoskeleton, which is essential for various cellular processes such as migration, division, and morphology. Its function is primarily associated with the modulation of cellular responses to mechanical and biochemical stimuli. Recent research underscores that WDR1 is involved in various physiological processes, including cell shape maintenance, wound healing, and immune responses. Dysregulation of WDR1 expression has been linked to several pathological conditions such as cancer metastasis, where altered cell motility contributes to the spread of tumor cells. Furthermore, studies indicate that WDR1 interacts with other actin-binding proteins to promote the disassembly of actin filaments, demonstrating its regulatory influence on the cytoskeletal dynamics. Given these insights, understanding the molecular mechanisms governing WDR1's function and its interactions within cellular pathways is crucial for developing therapeutic strategies targeting diseases characterized by cytoskeletal abnormalities. Research into WDR1 recombinant proteins not only aids in elucidating these mechanisms but also provides a platform for investigating potential drug targets aimed at correcting the cellular dysfunctions associated with WDR1. The ongoing exploration of WDR1's roles could offer significant advancements in both basic biological research and clinical applications, highlighting its relevance as a focal point in the study of cell biology and disease progression.
