Analytical Data
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基因名
SAA1
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简介
Serum Amyloid A-1 Protein, a vital acute phase protein, primarily exists as a homohexamer composed of dimers of trimers.Although it can form amyloid fibrils after partial proteolysis, the native, undenatured form does not exhibit amyloid fibril formation in vitro.Serving as an apolipoprotein within the HDL complex, Serum Amyloid A-1 also shows affinity for heparin binding, highlighting its multifaceted role in biological processes.SAA1 Protein, Mouse (His) is the recombinant mouse-derived SAA1 protein, expressed by E.coli , with N-6*His labeled tag.
- Application
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生物活性
Measured by its ability to induce TNF-alpha secretion by J774A.1 mouse reticulum cell sarcoma macrophage cells. The ED 50 for this effect is 4.689 μg/mL. Measured by its ability to induce TNF-alpha secretion by J774A.1 mouse reticulum cell sarcoma macrophage cells. The ED50 for this effect is 4.689 μg/mL. Corresponding to a specific activity is 213.265 U/mg.
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别名
Serum Amyloid A-1 Protein; SAA; SAA1
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种属
Mouse
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P05366
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表达区间
G20-Y122
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蛋白长度
Full Length of Mature Protein
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分子量
13-17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SAA1, or Serum Amyloid A1, is an acute-phase protein primarily synthesized by the liver in response to inflammation and tissue injury. It plays a crucial role in the body's innate immune response and has been implicated in various pathological conditions, including cardiovascular diseases, amyloidosis, and metabolic disorders. Research on SAA1 has gained considerable attention due to its potential as a biomarker for inflammation and disease prognosis. Recombinant SAA1 protein has emerged as a valuable tool in scientific studies, allowing researchers to investigate its biological functions, interactions with other molecules, and effects on immune responses in controlled settings. The ability to produce SAA1 recombinantly facilitates the exploration of its role in disease mechanisms and therapeutic applications, particularly in understanding how variations in SAA1 expression can influence inflammatory responses and contribute to chronic diseases. Furthermore, ongoing studies aim to elucidate the structural and functional aspects of this protein, advancing our knowledge of its pathophysiological implications and paving the way for potential interventions targeting SAA1-related pathways in various disease contexts. Overall, the investigation of SAA1 and its recombinant forms continues to hold promise for enhancing our understanding of immune responses and developing novel therapeutic strategies.
