Analytical Data
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基因名
GPR161
- Application
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别名
G-protein coupled receptor RE2
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N6U8
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表达区间
1-28aa
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分子量
30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR161, a member of the G protein-coupled receptor (GPCR) family, plays a crucial role in various physiological processes, including neural development and the regulation of signaling pathways associated with the Hedgehog (Hh) signaling cascade. Research on GPR161 has garnered significant interest due to its implications in developmental biology and potential involvement in tumorigenesis. Aberrant signaling through the Hedgehog pathway, in which GPR161 is implicated as a negative regulator, is often linked to several cancers, notably basal cell carcinoma and medulloblastoma. The receptor's ability to modulate cell proliferation and differentiation makes it a key target for therapeutic interventions. The study of GPR161 recombinant proteins enables researchers to better understand its structural characteristics, functional roles, and interactions with other signaling molecules. By producing and characterizing recombinant GPR161, scientists aim to elucidate the mechanisms by which this receptor influences cellular responses and to explore its potential as a drug target. Investigating the receptor's specific domains, ligand-binding properties, and downstream signaling pathways can provide valuable insights into its function in normal development and disease states, ultimately informing the design of novel therapeutic strategies aimed at modulating GPR161 activity in pathological conditions.
