Analytical Data
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Gene name
GPR161
- Application
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Alternative Names
G-protein coupled receptor RE2
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N6U8
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Expression Region
1-28aa
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Molecular Weight
30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GPR161, a member of the G protein-coupled receptor (GPCR) family, plays a crucial role in various physiological processes, including neural development and the regulation of signaling pathways associated with the Hedgehog (Hh) signaling cascade. Research on GPR161 has garnered significant interest due to its implications in developmental biology and potential involvement in tumorigenesis. Aberrant signaling through the Hedgehog pathway, in which GPR161 is implicated as a negative regulator, is often linked to several cancers, notably basal cell carcinoma and medulloblastoma. The receptor's ability to modulate cell proliferation and differentiation makes it a key target for therapeutic interventions. The study of GPR161 recombinant proteins enables researchers to better understand its structural characteristics, functional roles, and interactions with other signaling molecules. By producing and characterizing recombinant GPR161, scientists aim to elucidate the mechanisms by which this receptor influences cellular responses and to explore its potential as a drug target. Investigating the receptor's specific domains, ligand-binding properties, and downstream signaling pathways can provide valuable insights into its function in normal development and disease states, ultimately informing the design of novel therapeutic strategies aimed at modulating GPR161 activity in pathological conditions.
