Analytical Data
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基因名
HO-1
- Application
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别名
P32 protein
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种属
Mouse
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表达系统
E. coli
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标签
N- His-B2M
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14901
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表达区间
1-289aa
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分子量
46.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Heme oxygenase-1 (HO-1) is an enzyme that plays a pivotal role in the catabolism of heme, leading to the production of biliverdin, carbon monoxide, and free iron. It is a key player in various physiological processes, including oxidative stress response, apoptosis, and inflammation, making it a crucial target for therapeutic interventions in various diseases. Research has increasingly focused on the upregulation of HO-1 as a cytoprotective mechanism, particularly in conditions such as ischemia-reperfusion injury, neurodegenerative disorders, and cardiovascular diseases. The enzyme's expression is often induced by various stressors and cytokines, highlighting its role as a regulatory protein in cellular defense mechanisms. Investigations into recombinant HO-1 protein have allowed scientists to explore its functional properties, potential therapeutic applications, and the molecular pathways involved in its action. Given its antioxidant and anti-inflammatory properties, recombinant HO-1 is being studied for its potential in the treatment of diseases characterized by oxidative stress and inflammation. Furthermore, understanding the regulatory mechanisms of HO-1 expression and activity may lead to novel strategies for enhancing its protective effects in clinical settings. Thus, the study of HO-1, particularly in its recombinant form, holds significant promise for the development of innovative therapeutic approaches aimed at mitigating tissue damage and improving outcomes in various pathological conditions.
