Analytical Data
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基因名
PHGDH
- Application
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别名
/
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43175
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表达区间
2-251aa
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分子量
53.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PHGDH (Phosphoglycerate Dehydrogenase) is an essential enzyme involved in the serine biosynthetic pathway, converting 3-phosphoglycerate to 3-phosphoserine, a precursor for the amino acid serine. Research on PHGDH has gained significant attention due to its pivotal role in cancer metabolism, particularly in numerous malignancies where it is often found to be overexpressed. Elevated levels of serine have been shown to support rapid cell proliferation and tumor growth, making PHGDH a potential target for therapeutic intervention. Additionally, PHGDH has been implicated in neurodevelopmental disorders and other metabolic diseases, further underscoring its biological importance. The generation of recombinant PHGDH proteins through methods such as heterologous expression in microbial systems allows for extensive biochemical characterization, structure-function studies, and potential drug discovery efforts aimed at modulating its activity. Overall, the investigation of PHGDH and its recombinant proteins represents a promising avenue for understanding metabolic regulation in health and disease, as well as for developing novel therapeutic strategies targeting cancer and other disorders linked to altered serine metabolism.
