Analytical Data
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Gene name
LRPAP1
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简介
Low density lipoprotein receptor-related protein associated protein 1 interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands.LRPAP1 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived LRPAP1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Biological Activity
Immobilized LRPAP1 at 2 μg/mL (100 μL/well) can bind Biotinylated VLDLR protein. The ED50 for this effect is 0.1294-0.5374 nM. Immobilized LRPAP1 at 2 μg/mL (100 μL/well) can bind Biotinylated VLDLR protein. The ED50 for this effect is 0.5374 nM.
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Alternative Names
Alpha-2-macroglobulin receptor-associated protein; Alpha-2-MRAP; RAP; A2MRAP
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q52KI7
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Expression Region
Q29-L360
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AA Sequence
QPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL
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Protein Length
Partial
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Molecular Weight
41.59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LRPAP1, or low-density lipoprotein receptor-related protein-associated protein 1, is a crucial protein involved in the endocytosis and cellular signaling of lipoprotein receptors, particularly in neuronal contexts. Its association with neurodegenerative diseases has garnered significant attention, as studies suggest that LRPAP1 may play a role in modulating the activity of the LRP family of receptors, influencing lipid metabolism and neuroinflammation. Research indicates that LRPAP1 could be implicated in pathways related to Alzheimer's disease and other forms of neurodegeneration, making it a potential biomarker and therapeutic target. The recombinant expression of LRPAP1 protein is vital for in-depth studies on its structural and functional properties, enabling researchers to explore its molecular interactions and effects on cell signaling. Understanding the precise role of LRPAP1 in cellular mechanisms could provide insights into neuroprotective strategies and novel treatment approaches for neurodegenerative disorders. As such, the establishment of recombinant LRPAP1 offers a promising avenue for advancing our knowledge in neurobiology and potential therapeutic applications.
