Analytical Data
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基因名
CHD5
- Application
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别名
ATP-dependent helicase CHD5
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TDI0
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表达区间
Arg712~Glu896
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHD5 (Chromodomain Helicase DNA-binding protein 5) is a member of the CHD family of proteins, which are characterized by the presence of chromodomains and ATPase/helicase motifs, playing crucial roles in chromatin remodeling and gene regulation. Recent studies have highlighted the significance of CHD5 in various biological processes, including its potential tumor suppressor functions. It has been implicated in neurodevelopmental disorders and cancer, particularly in neuroblastoma, where loss of CHD5 expression is associated with poor prognosis. Research into CHD5 recombinant proteins aims to uncover its functional mechanisms and interactions with other cellular components, providing insights into its role in chromatin dynamics and gene expression regulation. Understanding the structural and functional properties of CHD5 could pave the way for novel therapeutic approaches, especially in cancer treatment, by targeting its pathways or restoring its expression. Additionally, elucidating the role of CHD5 in epigenetic modifications may contribute to a broader understanding of how chromatin remodeling affects cellular processes and disease states.
