Analytical Data
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Gene name
CTNNa1
- Application
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Alternative Names
CTNN-A1; aCat; CAP102; Cadherin Associated Protein Alpha 1; Alpha E-catenin; Renal carcinoma antigen NY-REN-13
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35221
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Expression Region
Thr2~Cys228
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CTNNa1 (Catenin Alpha 1) is a crucial protein involved in cell adhesion and signal transduction, serving as a central component of adherens junctions that link the cytoskeleton to the cell membrane. Understanding the functional dynamics of CTNNa1 is essential, as it plays a significant role in various biological processes, including tissue development, maintenance of cell structure, and cell signaling pathways that regulate cellular proliferation and differentiation. Aberrant expression or mutations in CTNNa1 have been implicated in several diseases, notably cancer, where they can disrupt normal cell adhesion and contribute to tumor progression and metastasis. The study of recombinant CTNNa1 protein allows researchers to explore its biochemical properties, interaction with other cellular proteins, and its role in cellular mechanics and pathology. By utilizing recombinant technology, scientists can produce large quantities of purified CTNNa1 for a variety of applications, including structural studies, functional assays, and drug discovery efforts targeting catenin-related pathways. Furthermore, the recombinant proteins can serve as valuable tools in elucidating the mechanisms underlying cadherin-mediated adhesion and related signaling cascades, facilitating the development of therapeutic strategies for diseases characterized by dysregulated catenin function. Overall, research on CTNNa1 recombinant protein holds promise for advancing our understanding of cell adhesion biology and its implications in health and disease.
