Analytical Data
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Gene name
FGFR-2 alpha (IIIb)
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简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
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Species
Human
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21802-3
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Expression Region
R22-E378
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Protein Length
Partial
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Molecular Weight
60-80 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 2 (FGFR2) is a crucial receptor involved in various biological processes, including cell proliferation, differentiation, and survival. Among its isoforms, FGFR2 alpha (IIIb) plays a significant role in development and tissue homeostasis, making it a key target in cancer research and therapeutic interventions. Aberrant FGFR2 signaling has been implicated in a variety of malignancies, including breast and gastric cancers, where it often contributes to tumor growth and metastasis. The study of recombinant FGFR2 alpha (IIIb) proteins aims to elucidate the mechanisms of FGFR2-mediated signaling pathways and their effects on cellular behavior. By generating these recombinant proteins, researchers can investigate FGFR2 interactions with ligands and other intracellular signaling molecules. Additionally, understanding the structural and functional characteristics of FGFR2 alpha (IIIb) can facilitate the development of specific inhibitors or therapeutic agents that target FGFR2-related pathways. This research is particularly crucial as it may offer novel strategies for overcoming resistance to existing cancer therapies and improving patient outcomes. In summary, the investigation of FGFR2 alpha (IIIb) recombinant proteins is pivotal in advancing our knowledge of its biological functions and therapeutic potentials in oncology.
