Analytical Data
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基因名
AKAP11
- Application
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别名
AKAP220; PRKA11; Protein Kinase A Anchoring Protein 11; A Kinase(PRKA)Anchor Protein 11; A-kinase anchor protein 220 kDa; Protein kinase A-anchoring protein 11
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKA4
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表达区间
Leu1650~Ala1901
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分子量
36kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP11 (A-kinase anchor protein 11) is a member of the A-kinase anchoring protein family, which plays a crucial role in the spatial and temporal regulation of protein kinase A (PKA) signaling pathways within cells. Research into AKAP11 has gained momentum due to its involvement in various physiological processes, including cell proliferation, differentiation, and apoptosis. Notably, it has been implicated in several diseases, such as cancer and cardiac disorders, where altered PKA signaling may contribute to pathophysiological changes. The ability of AKAPs to anchor PKA and other signaling molecules to specific cellular locations allows for precise modulation of signaling cascades, thereby influencing numerous cellular functions. Given these associations, the recombinant expression of AKAP11 can facilitate the understanding of its structure-function relationships and its role in signal transduction. By producing AKAP11 in a laboratory setting, researchers can study its binding interactions with PKA, as well as its potential regulatory mechanisms in cellular pathways. Furthermore, the generation of recombinant AKAP11 provides a valuable tool for investigating the therapeutic potentials by targeting PKA localization in disease contexts, making it an important focus in molecular and cellular biology research.
