Analytical Data
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Gene name
SNX13
- Application
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Alternative Names
RGS-PX1; RGS domain- and PHOX domain-containing protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5W8
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Expression Region
Ala97~Asn284
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNX13 (Sorting Nexin 13) is a member of the sorting nexin family, which plays crucial roles in intracellular transport and membrane trafficking processes. This protein is particularly important in endosomal sorting and retrieval pathways, contributing to the regulation of protein localization and cellular signaling. Recent studies have highlighted the involvement of SNX13 in various cellular functions, including the processing of membrane proteins and the modulation of intracellular signaling pathways, which are essential for maintaining cellular homeostasis. Dysregulation of SNX13 has been associated with several disease states, including neurodegenerative disorders and cancer, making it a potential therapeutic target. The recombinant protein form of SNX13 is crucial for studying its structure-function relationships and interactions with other cellular components. By producing and characterizing SNX13 as a recombinant protein, researchers aim to elucidate its mechanisms of action within the cell, understand how mutations may affect its function, and uncover its role in disease pathology. This research could lead to new insights into targeted therapies that leverage the normal functioning of SNX13 or correct for its dysfunction in disease contexts. Understanding the detailed biophysical properties and the interaction dynamics of SNX13 in a controlled environment allows for a more comprehensive grasp of its biological significance and potential therapeutic applications.
