Analytical Data
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基因名
Neuroligin-1NLGN1
- Application
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别名
Neuroligin-1; NLGN1; KIAA1070
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种属
Mouse
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99K10-1
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表达区间
Q46-S697
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氨基酸序列
QKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELS
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蛋白长度
Extracellular Domain
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分子量
80-125 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neuroligin-1 (NLGN1) is a postsynaptic cell-adhesion molecule that plays a crucial role in synapse formation and function in the central nervous system. It is encoded by the NLGN1 gene and is known to interact with presynaptic neurexins, thereby facilitating the establishment and maintenance of excitatory synapses. Dysregulation of NLGN1 has been implicated in various neurological disorders, including autism spectrum disorders, schizophrenia, and intellectual disabilities. Research has increasingly focused on characterizing the structure and function of NLGN1 to understand its role in synaptic plasticity and neural circuitry. The recombinant expression of NLGN1 protein in heterologous systems provides a valuable tool for studying its biochemical properties, interaction dynamics with neurexins, and its impact on neuronal signaling pathways. By generating recombinant NLGN1, researchers aim to elucidate how specific mutations in the NLGN1 gene can affect protein function and contribute to neurodevelopmental disorders. This approach enables the identification of potential therapeutic targets and the development of strategies for intervention in related pathologies. Overall, the study of recombinant NLGN1 protein is essential for advancing our understanding of synaptic biology and its implications in health and disease.
