Analytical Data
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Gene name
LAMa3
- Application
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Alternative Names
LAM-A3; E170; LAMNA; LOCS; Lama3a; Nicein subunit alpha; Kalinin subunit alpha; Epiligrin subunit alpha
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16787
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Expression Region
Gln47~Leu296
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LAMa3, a key component of the laminin protein family, plays a crucial role in the structure and function of basement membranes, which are vital for tissue integrity and cellular signaling. Research into LAMa3 recombinant proteins has gained momentum due to their potential applications in regenerative medicine, wound healing, and tissue engineering. Laminins, including LAMa3, are essential for cellular adhesion, migration, and differentiation, making them critical in various biological processes. The generation of LAMa3 recombinant proteins allows for the study of their specific interactions with cells and extracellular matrix components. This research is particularly important in understanding diseases related to basement membrane dysfunction, such as muscular dystrophies, cancer, and other genetic disorders. Moreover, the ability to produce LAMa3 in vitro provides opportunities for developing novel therapeutic strategies that harness its properties for enhancing tissue repair and regeneration. This avenue of research not only contributes to the basic understanding of cell-matrix interactions but also paves the way for innovative treatments in the fields of biomaterials and tissue engineering, addressing significant clinical challenges related to tissue injuries and degenerative diseases.
