Analytical Data
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基因名
DUOX2
- Application
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别名
LNOX2; NOXEF2; THOX2; Thyroid oxidase 2; NADH/NADPH thyroid oxidase p138-tox; Dual Oxidase-Like Domains 2; Nicotinamide Adenine Dinucleotide Phosphate Oxidase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NRD8
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表达区间
Gln26~Thr601
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分子量
68kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUOX2 (dual oxidase 2) is an enzyme that plays a critical role in the generation of reactive oxygen species (ROS), particularly in the thyroid gland and the gastrointestinal tract. This enzyme is essential for thyroid hormone production and has been implicated in various physiological and pathological processes, including innate immunity and inflammatory responses. Abnormal DUOX2 function is linked to several disorders, such as congenital hypothyroidism and certain autoimmune diseases. The study of DUOX2 recombinant proteins is pivotal for understanding its structure-function relationship and regulatory mechanisms. These recombinant proteins can be used to elucidate the enzymatic activity and explore the biochemical pathways involving DUOX2. Additionally, research into DUOX2 can provide insights into potential therapeutic targets for diseases associated with oxidative stress and dysregulated immune responses. Advances in recombinant DNA technology have facilitated the production of DUOX2 proteins in various systems, enabling comprehensive investigations into their bioactivity and interactions with other cellular components. Overall, the ongoing research on DUOX2 not only enhances our understanding of thyroid physiology but also contributes to the broader field of oxidative stress research and its implications for human health.
