Analytical Data
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Gene name
RPS19BP1
- Application
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Alternative Names
40S ribosomal protein S19-binding protein 1 Short name: RPS19-binding protein 1 Short name: S19BP
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86WX3
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Expression Region
1-145aa
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Molecular Weight
42.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPS19BP1, known as Ribosomal Protein S19 Binding Protein 1, plays a significant role in cellular functions and has garnered attention in the field of molecular biology and medicine. This protein is closely associated with the ribosome biogenesis process, where it is believed to interact with ribosomal proteins, thus influencing protein synthesis and cellular growth. Understanding RPS19BP1 is crucial, as it is implicated in several diseases, including cancers and genetic disorders like Diamond-Blackfan anemia—a condition resulting from mutations in ribosomal protein genes. Recent studies have highlighted the potential of RPS19BP1 in modulating cellular responses to stress and its involvement in oncogenic pathways, making it a target for therapeutic interventions. The reconstitution and characterization of RPS19BP1 as a recombinant protein offer valuable insights into its structure-function relationship, enabling the exploration of its biochemical properties and interactions with other cellular macromolecules. This research is pivotal for grasping the nuances of ribosomal assembly and function, ultimately providing a foundation for developing strategies to mitigate disorders associated with its dysregulation.
