Analytical Data
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Gene name
GRIK2
- Application
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Alternative Names
EAA4; GLR6; GLUR6; GluK2; Excitatory amino acid receptor 4; Glutamate receptor 6
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13002
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Expression Region
Asn286~Pro561
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GRIK2, a gene encoding the Glutamate Ionotropic Receptor Kainate Type Subunit 2, plays a crucial role in synaptic transmission and neurological processes, particularly in learning and memory. Dysregulation of GRIK2 has been associated with various neuropsychiatric disorders, including schizophrenia, depression, and epilepsy. To better understand its function and therapeutic potential, researchers have focused on producing recombinant GRIK2 proteins. These recombinant proteins allow for detailed biochemical and pharmacological studies, enabling scientists to investigate the structure-function relationships of the receptor, its interaction with ligands, and its signaling pathways. Advances in protein expression techniques, such as using mammalian cell systems, have improved the yield and functionality of recombinant GRIK2, making it a valuable tool for studying receptor dynamics in vitro. Furthermore, the development of high-throughput screening assays utilizing these recombinant proteins holds promise for discovering novel compounds that can modulate GRIK2 activity. Understanding the precise role of GRIK2 in neuronal function could pave the way for targeted therapies to treat related neurological conditions, thereby highlighting the significance of GRIK2 recombinant protein research in neuroscience.
