Analytical Data
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基因名
XPD
- Application
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别名
CXPD; BTF2 p80; EM9; TTD; ERCC2; TFIIH basal transcription factor complex 80 kDa; De Sanctis-Cacchione; Excision Repair Cross-Complementing Rodent Repair Deficiency 2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18074
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表达区间
Ala404~Leu637
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XPD, also known as ERCC2, is a critical gene that encodes a protein involved in the nucleotide excision repair (NER) pathway, which is essential for the repair of bulky DNA lesions caused by environmental factors such as UV radiation and certain chemicals. Mutations in the XPD gene can lead to a variety of disorders, including xeroderma pigmentosum, which is characterized by extreme sensitivity to sunlight and a significantly increased risk of skin cancer. Additionally, XPD has been implicated in other conditions such as trichothiodystrophy and certain xeroderma pigmentosum variant forms, highlighting its importance in maintaining genomic stability. Research on XPD recombinant proteins has gained momentum due to their potential therapeutic applications in gene therapy and cancer treatment. By producing recombinant XPD proteins, scientists aim to elucidate the protein’s structure-function relationships, investigate its interactions with other NER proteins, and develop strategies to enhance DNA repair mechanisms in cells with XPD deficiencies. Understanding the functional dynamics of XPD through recombinant technologies could pave the way for novel interventions in genetic disorders associated with defective DNA repair systems and may provide insights into cancer susceptibility linked to DNA repair deficiencies. This line of research not only holds promise for advancing molecular biology and genetics but also for developing innovative approaches to cancer treatment and prevention.
