Analytical Data
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Gene name
JAG1
- Application
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Alternative Names
CD339; AGS; AHD; AWS; HJ1; JAGL1; Alagille Syndrome; Jagged 1 Protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78504
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Expression Region
Gly33~Asp250
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
JAG1 (Jagged1) is a crucial ligand in the Notch signaling pathway, which plays a vital role in various biological processes, including cell differentiation, proliferation, and apoptosis. The Notch pathway is fundamental in developmental biology, influencing cell fate decisions during embryogenesis and tissue homeostasis. Dysregulation of JAG1 and its associated signaling has been implicated in numerous diseases, such as cancers, developmental disorders, and cardiovascular diseases. Given its significance, researchers have increasingly focused on the production of recombinant JAG1 proteins to study their structure-function relationships and biological activities. These recombinant proteins facilitate detailed investigations into the mechanisms of Notch signaling and its implications in health and disease. Furthermore, understanding JAG1's role in various cellular contexts can lead to the identification of novel therapeutic targets and strategies for treating Notch-related disorders. The advancement of protein engineering techniques has enabled the generation of functional JAG1 variants, thus enhancing the ability to explore its interactions with Notch receptors and downstream signaling components in different cellular environments. Consequently, research on recombinant JAG1 proteins is crucial for elucidating the complexities of the Notch signaling pathway and developing potential interventions for related pathologies.
