Analytical Data
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基因名
IL-31
- Application
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别名
IL-31,
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q6EBC2
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表达区间
24-164aa
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分子量
15.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-31 (IL-31) is a cytokine primarily produced by activated T-helper cells, particularly Th2 cells, and is known to play a critical role in allergic responses and inflammation. Research has identified IL-31 as a significant mediator in various dermatological conditions, most notably atopic dermatitis, where it is associated with pruritus (itching) and skin inflammation. Elevated levels of IL-31 have been observed in patients suffering from these conditions, indicating its potential as a therapeutic target. The development of recombinant IL-31 proteins has gained attention in the scientific community, as understanding the molecular mechanisms and pathways associated with IL-31 can lead to novel treatment strategies for inflammatory diseases. Moreover, exploring the structure-function relationship of IL-31 through recombinant protein studies can elucidate its interaction with receptors and downstream signaling pathways. By investigating the effects of IL-31 in preclinical models and assessing the therapeutic potential of IL-31 blockade or modulation, researchers aim to provide new insights into the pathophysiology of allergic inflammation and develop targeted therapies to alleviate symptoms associated with IL-31-driven conditions. Overall, the exploration of IL-31 recombinant proteins is pivotal in advancing our understanding of cytokine-mediated inflammation and could pave the way for innovative approaches in the management of itchy skin disorders and other related ailments.
