Analytical Data
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基因名
DDB1
- Application
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别名
XAP1
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种属
Human
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16531-1
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表达区间
S2-H1140
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
128.9 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDB1 (Damage-specific DNA-binding protein 1) is a crucial component of the DNA damage recognition and repair pathway, particularly in the context of nucleotide excision repair (NER). It forms a part of the DDB complex, which plays a pivotal role in recognizing and binding to DNA lesions caused by ultraviolet (UV) radiation and other DNA-damaging agents. Research has highlighted that DDB1 not only facilitates the recruitment of repair factors to sites of damage but also serves as a substrate adaptor for cullin-RING E3 ubiquitin ligases, thereby influencing protein degradation and cellular responses to DNA damage. Misregulation of DDB1 has been implicated in various cancers, making it a potential target for therapeutic interventions. Furthermore, the study of recombinant DDB1 protein is essential for understanding its structural and functional dynamics in DNA repair mechanisms. Characterizing DDB1 through recombinant expression systems allows for in-depth investigations into its interaction with DNA and other protein partners, elucidating its role in maintaining genomic stability. Overall, the research on DDB1 and its recombinant forms contributes significantly to our understanding of the molecular basis of DNA repair processes and their implications in disease.
