Analytical Data
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Gene name
ADCY8
- Application
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Alternative Names
HBAC1; AC8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Ca(2+)/calmodulin-activated adenylyl cyclase
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40145
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Expression Region
His915~Pro1251
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Molecular Weight
40kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADCY8 (Adenylate Cyclase 8) is an enzyme that plays a critical role in the synthesis of cyclic adenosine monophosphate (cAMP), a vital second messenger involved in various physiological processes, including signal transduction, hormone regulation, and neural communication. The importance of ADCY8 in these pathways has led to increasing interest in its role in health and disease, particularly in neurological disorders, metabolic conditions, and cardiovascular diseases. Research has demonstrated that ADCY8 is implicated in modulating neuronal excitability and plasticity, influencing learning and memory. This makes it a potential target for therapeutic interventions aimed at treating cognitive impairments or psychiatric disorders. Moreover, the dysfunction of ADCY8 has been linked to pathologies such as heart failure and obesity, underscoring its significance in metabolic regulation and cardiovascular health. Recent advancements in recombinant protein technology have enabled the expression and purification of ADCY8, allowing for structural and functional studies that enhance our understanding of its mechanisms. By studying the recombinant ADCY8 protein, researchers aim to elucidate its enzymatic activity, interactions with other molecules, and effects on cellular signaling pathways, thereby providing insights into its role in both normal physiology and disease states. Consequently, investigations into ADCY8 offer promising avenues for the development of novel therapeutic strategies targeting cAMP signaling, which could yield beneficial outcomes in various clinical applications.
