Analytical Data
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基因名
ADCY8
- Application
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别名
HBAC1; AC8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Ca(2+)/calmodulin-activated adenylyl cyclase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P40145
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表达区间
His915~Pro1251
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分子量
40kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADCY8 (Adenylate Cyclase 8) is an enzyme that plays a critical role in the synthesis of cyclic adenosine monophosphate (cAMP), a vital second messenger involved in various physiological processes, including signal transduction, hormone regulation, and neural communication. The importance of ADCY8 in these pathways has led to increasing interest in its role in health and disease, particularly in neurological disorders, metabolic conditions, and cardiovascular diseases. Research has demonstrated that ADCY8 is implicated in modulating neuronal excitability and plasticity, influencing learning and memory. This makes it a potential target for therapeutic interventions aimed at treating cognitive impairments or psychiatric disorders. Moreover, the dysfunction of ADCY8 has been linked to pathologies such as heart failure and obesity, underscoring its significance in metabolic regulation and cardiovascular health. Recent advancements in recombinant protein technology have enabled the expression and purification of ADCY8, allowing for structural and functional studies that enhance our understanding of its mechanisms. By studying the recombinant ADCY8 protein, researchers aim to elucidate its enzymatic activity, interactions with other molecules, and effects on cellular signaling pathways, thereby providing insights into its role in both normal physiology and disease states. Consequently, investigations into ADCY8 offer promising avenues for the development of novel therapeutic strategies targeting cAMP signaling, which could yield beneficial outcomes in various clinical applications.












