Analytical Data
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基因名
TRPM4
- Application
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别名
TRPM4B; Melastatin-4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7TN37
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表达区间
Met1~Leu450
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分子量
57kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRPM4 (transient receptor potential melastatin 4) is a calcium-activated monovalent cation channel that plays a crucial role in various physiological processes, including cardiac function, neuronal excitability, and immune responses. Research on TRPM4 has gained momentum due to its involvement in several diseases, such as cardiac arrhythmias, hypertension, and neurodegenerative disorders. The channel is known to influence cell membrane potential and intracellular calcium levels, thereby modulating cellular signaling pathways. Because of its importance in health and disease, understanding the mechanistic details of TRPM4 function is essential. Recombinant protein studies of TRPM4 facilitate the examination of its structure, gating mechanisms, and interaction with other cellular components. These studies often involve the expression of TRPM4 in heterologous systems, allowing researchers to isolate the protein and analyze its biophysical properties. Additionally, TRPM4 serves as a potential therapeutic target, making its detailed characterization significant for drug discovery efforts. Overall, research on TRPM4 recombinant protein not only enhances our understanding of its biological roles but also opens up avenues for novel therapeutic interventions in diseases associated with TRPM4 dysregulation.
