Analytical Data
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基因名
FZR1
- Application
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别名
CDC20-like protein 1Cdh1/Hct1 homolog ;hCDH1
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UM11
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表达区间
1-493aa
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分子量
70.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FZR1, also known as the Fizzy-related protein 1, is a crucial component in the regulation of the cell cycle, particularly in the management of the anaphase-promoting complex/cyclosome (APC/C). This protein plays a pivotal role in cell division by facilitating the degradation of key mitotic regulators, thus ensuring timely progression through the cell cycle phases. Research into FZR1 has gained importance due to its implications in cancer biology, where dysregulation of cell cycle control often leads to tumorigenesis. Furthermore, studies have shown that FZR1 is involved in various cellular processes beyond cell cycle regulation, including differentiation and development. Investigating the structure and function of recombinant FZR1 protein can provide insights into its regulatory mechanisms and potential interactions with other cell cycle proteins. Additionally, the development of FZR1 as a recombinant protein opens avenues for therapeutic applications, including targeted cancer therapies that aim to restore normal cell cycle function. Understanding FZR1’s role at a molecular level could reveal novel strategies for combatting diseases characterized by unregulated cell proliferation, thereby advancing the fields of cell biology and cancer research. Overall, the study of FZR1 not only enriches our knowledge of the basic principles of cell cycle regulation but also holds promise for clinical advancements in the treatment of cancer and other related disorders.
